| Identification | Back Directory | [Name]
N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) | [CAS]
2112737-60-5 | [Synonyms]
WUN 37605
N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) | [Molecular Formula]
C29H52N2O11 | [MDL Number]
MFCD30730360 | [MOL File]
2112737-60-5.mol | [Molecular Weight]
604.73 |
| Chemical Properties | Back Directory | [density ]
1.096±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, protect from light | [form ]
Liquid | [pka]
6.90±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a branched crosslinker molecule with two terminal propargyl groups and a t-Boc protected aminooxy group. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The protected amine can be deprotected under acidic conditions. | [Uses]
N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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