| Identification | Back Directory | [Name]
Boc-Aminooxy-PEG2-amine | [CAS]
252378-69-1 | [Synonyms]
Boc-Aminooxy-PEG2-amine
BOC-Aminooxy -PEG2-Amino
t-Boc-Aminooxy-PEG2-amine
Boc-Aminooxy-PEG2-C2-amine
3,6,9-Trioxa-2-azaundecanoic acid, 11-amino-, 1,1-dimethylethyl ester | [Molecular Formula]
C11H24N2O5 | [MDL Number]
MFCD29079399 | [MOL File]
252378-69-1.mol | [Molecular Weight]
264.32 |
| Chemical Properties | Back Directory | [density ]
1.077±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [form ]
Viscous Liquid | [pka]
8.74±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG2-amine contains a Boc-protected aminooxy group and a free amino(NH2) group. Amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc- aminooxy can be deprotected under mild acidic conditions and then reacts with an aldehyde to form a linkage. | [Uses]
Boc-Aminooxy-PEG2-C2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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