| Identification | Back Directory | [Name]
E3 ligase Ligand-Linker Conjugates 50 | [CAS]
2271036-44-1 | [Synonyms]
Pomalidomide-PEG1-C2-N3
Cereblon Ligand-Linker Conjugates 13
E3 ligase Ligand-Linker Conjugates 50
4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | [Molecular Formula]
C17H18N6O5 | [MDL Number]
MFCD32197214 | [MOL File]
2271036-44-1.mol | [Molecular Weight]
386.37 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, stored under nitrogen | [form ]
Solid | [color ]
Light yellow to yellow | [InChIKey]
NJPMWHWTBBYBDY-UHFFFAOYSA-N | [SMILES]
[N-]=[N+]=NCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3 |
| Hazard Information | Back Directory | [Uses]
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1]. Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [Biological Activity]
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1]. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2. |
|
|