| Identification | Back Directory | [Name]
E3 Ligase Ligand-Linker Conjugates 22 | [CAS]
2225940-52-1 | [Synonyms]
Pomalidomide-PEG4-C2-NH2
Cereblon Ligand-Linker Conjugates 8
E3 Ligase Ligand-Linker Conjugates 22
4-((14-amino-3,6,9,12-tetraoxatetradecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 4-[(14-amino-3,6,9,12-tetraoxatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)- | [Molecular Formula]
C23H32N4O8 | [MDL Number]
MFCD31715437 | [MOL File]
2225940-52-1.mol | [Molecular Weight]
492.52 |
| Chemical Properties | Back Directory | [Boiling point ]
714.3±60.0 °C(Predicted) | [density ]
1.335±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.74±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Pomalidomide-PEG4-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. | [IC 50]
Cereblon | [References]
[1] Jian Jin, et al. Compositions and methods for treating ezh2-mediated cancer. WO2018081530A1. |
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