| Identification | Back Directory | [Name]
E3 Ligase Ligand-Linker Conjugates 1 | [CAS]
2097938-44-6 | [Synonyms]
Pomalidomide-PEG4-C-COOH
E3 Ligase Ligand-Linker Conjugate 1
Cereblon Ligand -Linker Conjugates 1
E3 Ligase Ligand-Linker Conjugates 1
4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecan-1-oic acid
2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
14-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihy
dro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetra
decanoic acid
Acetic acid, 2-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]- | [Molecular Formula]
C23H29N3O10 | [MDL Number]
MFCD31540390 | [MOL File]
2097938-44-6.mol | [Molecular Weight]
507.49 |
| Chemical Properties | Back Directory | [Boiling point ]
769.8±60.0 °C(Predicted) | [density ]
1.410±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, stored under nitrogen | [form ]
Oil | [pka]
3.39±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Pomalidomide-PEG4-C-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. | [IC 50]
Cereblon | [References]
[1] Guangrong Zheng, et al. Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof. WO2017184995A1. |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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