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2158322-33-7

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2158322-33-7 Structure

2158322-33-7 Structure
IdentificationBack Directory
[Name]

PAC
[CAS]

2158322-33-7
[Synonyms]

[Molecular Formula]

C94H107N13O16
[MDL Number]

MFCD31657411
[MOL File]

2158322-33-7.mol
[Molecular Weight]

1674.97
Chemical PropertiesBack Directory
[density ]

1.33±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

13.13±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

PROTAC ERα Degrader-5 (compound LP2) consists an ADC linker and a PROTAC, whcih can be conjugated to an antibody to form PACs. PROTAC ERα Degrader-5 conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab)[1].
[References]

[1] Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.
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