| Identification | Back Directory | [Name]
L-Prolinamide, N-(4-carboxy-1-oxobutyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [CAS]
2172819-73-5 | [Synonyms]
(S,R,S)-AHPC-CO-C3-acid VH 032 amide-alkylC3-acid L-Prolinamide, N-(4-carboxy-1-oxobutyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- 5-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentanoic acid | [Molecular Formula]
C27H36N4O6S | [MDL Number]
MFCD32903592 | [MOL File]
2172819-73-5.mol | [Molecular Weight]
544.66 |
| Chemical Properties | Back Directory | [Boiling point ]
879.1±65.0 °C(Predicted) | [density ]
1.288±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
powder | [pka]
4?+-.0.10(Predicted) | [InChIKey]
FKGREQKARAJLQH-JXALWOEJSA-N | [SMILES]
C([C@@H](NC(CCCC(O)=O)=O)C(C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1 |
| Hazard Information | Back Directory | [Description]
VH 032 amide-alkylC3-acid is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC? research and development. It incorporates an E3 ligase ligand plus alkylC3 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. VH 032 amide-alkylC3-acid is part of a range of functionalized tool molecules for PROTAC R&D. | [Uses]
(S,R,S)-AHPC-C3-COOH (compound 28i) is a carboxylic acid derivative of the VHL E3 ubiquitin ligase ligand-Linker conjugate. (S,R,S)-AHPC-C3-COOH can be used to synthesize PROTACs[1]. | [storage]
Store at -20°C | [References]
[1] Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298. DOI:10.1021/acs.jmedchem.9b01264 |
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