| Identification | Back Directory | [Name]
L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [CAS]
2172819-72-4 | [Synonyms]
VH 032 amide-alkylC2-acid
(S,R,S)-AHPC-amido-C2-acid
L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid | [Molecular Formula]
C26H34N4O6S | [MOL File]
2172819-72-4.mol | [Molecular Weight]
530.64 |
| Chemical Properties | Back Directory | [Boiling point ]
868.3±65.0 °C(Predicted) | [density ]
1.306±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
methanol, ethyl acetate, DCM, THF, DMF, DMSO | [form ]
Solid | [pka]
4.70±0.10(Predicted) | [color ]
Off-white to light yellow | [Appearance]
beige powder |
| Hazard Information | Back Directory | [Description]
(S,R,S)-AHPC-amido-C2-acid is a VHL ligand with a 2 carbon alkyl linker and terminal acid for PROTAC compounds. | [Uses]
(S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand that can be used in PROTAC research and development. (S,R,S)-CO-C2-acid contains an E3 ligand alkyl ligand for conjugation of target protein ligands[1]. | [storage]
Store at -20°C | [References]
[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. DOI:10.1021/acs.jmedchem.6b01912 |
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