| Identification | Back Directory | [Name]
APN-C3-PEG4-alkyne | [CAS]
2183440-36-8 | [Synonyms]
APN-C3-PEG4-alkyne
9,12,15,18-Tetraoxa-5-azaheneicos-20-ynamide, N-[4-(2-cyanoethynyl)phenyl]-6-oxo- | [Molecular Formula]
C25H31N3O6 | [MDL Number]
MFCD31580143 | [MOL File]
2183440-36-8.mol | [Molecular Weight]
469.53 |
| Hazard Information | Back Directory | [Description]
APN-C3-PEG4-alkyne is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and an alkyne group. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation. | [Uses]
APN-C3-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. APN-C3-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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