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2194563-84-1

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2194563-84-1 Structure

2194563-84-1 Structure
IdentificationBack Directory
[Name]

Methyltetrazine-PEG4-NH-Boc
[CAS]

2194563-84-1
[Synonyms]

Methyltetrazine-PEG4-NH-Boc
tert-Butyl (2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate
[Molecular Formula]

C22H33N5O6
[MDL Number]

MFCD31615440
[MOL File]

2194563-84-1.mol
[Molecular Weight]

463.53
Chemical PropertiesBack Directory
[density ]

1.166±0.06 g/cm3(Predicted)
[solubility ]

Soluble in DMSO, DCM, DMF
[pka]

12.22±0.46(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
Hazard InformationBack Directory
[Description]

Methyltetrazine-PEG4-NH-Boc is a click chemistry reagent attached with a Boc protecting group. The hydrophilic PEG spacer arm improves water solubility and is transferrable to the labeled molecule, reducing aggregation of labeled proteins stored in solution. The Boc protecting group can be removed under acidic conditions.
[Uses]

Methyltetrazine-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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