| Identification | Back Directory | [Name]
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-[5-O-(aminosulfonyl)-2-deoxy-β-D-erythro-pentofuranosyl]-3-(methylthio)- | [CAS]
2226229-76-9 | [Synonyms]
ATG7-IN-3
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-[5-O-(aminosulfonyl)-2-deoxy-β-D-erythro-pentofuranosyl]-3-(methylthio)- | [Molecular Formula]
C11H16N6O5S2 | [MOL File]
2226229-76-9.mol | [Molecular Weight]
376.41 |
| Chemical Properties | Back Directory | [Boiling point ]
732.7±70.0 °C(Predicted) | [density ]
2.01±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.15±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ATG7-IN-3 (compound 18) is a potent ATG7 inhibitor, with an IC50 of 0.048 μM. ATG7-IN-3 inhibits autophagy. ATG7-IN-3 inhibits the formation of endogenous LC3B puncta in the neuroglioma cell line H4[1]. | [References]
[1] Huang SC, et al. Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors. Bioorg Med Chem. 2020 Oct 1;28(19):115681. DOI:10.1016/j.bmc.2020.115681 |
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