| Identification | Back Directory | [Name]
Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]- | [CAS]
2244452-09-1 | [Synonyms]
BI-4924
BI4924,BI 4924
Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]- | [Molecular Formula]
C21H20Cl2N2O6S | [MDL Number]
MFCD32197236 | [MOL File]
2244452-09-1.mol | [Molecular Weight]
499.36 |
| Chemical Properties | Back Directory | [Boiling point ]
860.6±65.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
2.51±0.10(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h[1]. | [References]
[1] Weinstabl H, et al. Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis. J Med Chem. 2019 Jul 31. DOI:10.1021/acs.jmedchem.9b00718 |
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