| Identification | Back Directory | [Name]
Thalidomide-linker 10 | [CAS]
2341841-02-7 | [Synonyms]
Thalidomide-linker 10
Thalidomide-O-amido-C2-NH2
-oxyacetamide-alkylC2-amine
Thalidomide-O-amido-C2-NH2 hydrochloride
Thalidomide 4'-oxyacetamide-alkyl-C2-amine (hydrochloride)
N-(2-aminoethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride | [Molecular Formula]
C17H19ClN4O6 | [MDL Number]
MFCD32705133 | [MOL File]
2341841-02-7.mol | [Molecular Weight]
410.81 |
| Hazard Information | Back Directory | [Uses]
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride can be used to design the PROTACs[1]. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2020;187:111952. DOI:10.1016/j.ejmech.2019.111952 |
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