| Identification | Back Directory | [Name]
Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- | [CAS]
2496687-00-2 | [Synonyms]
Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- | [Molecular Formula]
C26H31N3O10 | [MOL File]
2496687-00-2.mol | [Molecular Weight]
545.54 |
| Chemical Properties | Back Directory | [Boiling point ]
787.7±60.0 °C(Predicted) | [density ]
1.334±0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
10.68±0.40(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Thalidomide-O-amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Thalidomide-O-amido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Cereblon | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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