| Identification | Back Directory | [Name]
N-Desthiobiotin-N-bis(PEG4-NHS ester) | [CAS]
2353409-61-5 | [Synonyms]
N-Desthiobiotin-N-bis(PEG4-NHS ester)
4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-[6-[(4R,5S)-5-methyl-2-oxo-4-imidazolidinyl]-1-oxohexyl]-, 1,31-bis(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C40H65N5O18 | [MDL Number]
MFCD31811455 | [MOL File]
2353409-61-5.mol | [Molecular Weight]
903.97 |
| Hazard Information | Back Directory | [Description]
N-Desthiobiotin-N-bis(PEG4-NHS ester) is a PEG linker containing two NHS esters groups and desthiobiotin, which is a modified form of biotin that bonds to avidin, streptavidin and other biotin-binding protein-based affinity columns and are recognized by anti-biotin antibodies. The NHS ester can label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
N-Desthiobiotin-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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