| Identification | Back Directory | [Name]
E3 ligase Ligand 11 | [CAS]
2357114-70-4 | [Synonyms]
cIAP1 ligand 2
E3 ligase Ligand 11
Benzyl ((S)-1-(((S)-1-Cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate | [Molecular Formula]
C34H40N4O6S | [MDL Number]
MFCD32215339 | [MOL File]
2357114-70-4.mol | [Molecular Weight]
632.77 |
| Hazard Information | Back Directory | [Uses]
cIAP1 ligand 2 is the LCL161 derivative based IAP ligand. cIAP1 ligand 2 can be connected to the ABL ligand for protein by a linker to form SNIPER. | [IC 50]
cIAP1 | [References]
[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168 |
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