| Identification | Back Directory | [Name]
E3 ligase Ligand-Linker Conjugates 38 | [CAS]
2095244-52-1 | [Synonyms]
cIAP1 Ligand-Linker Conjugates 12
E3 ligase Ligand-Linker Conjugates 38
Benzenesulfonic acid, 4-methyl-, 2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl ester | [Molecular Formula]
C46H64N4O12S2 | [MDL Number]
MFCD32197269 | [MOL File]
2095244-52-1.mol | [Molecular Weight]
929.15 |
| Hazard Information | Back Directory | [Uses]
cIAP1 Ligand-Linker Conjugates 12 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 12 can be used to design SNIPERs[1]. | [IC 50]
cIAP1 | [References]
[1] Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570. DOI:10.1074/jbc.M116.768853 |
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