| Identification | Back Directory | [Name]
Propanoic acid, 3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- | [CAS]
2369068-42-6 | [Synonyms]
JUN 68426
Thalidomide-O-C2-acid
Thalidomide 4'-ether-alkylC2-acid
3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)propanoic acid
Propanoic acid, 3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- | [Molecular Formula]
C16H14N2O7 | [MOL File]
2369068-42-6.mol | [Molecular Weight]
346.29 |
| Chemical Properties | Back Directory | [Boiling point ]
640.0±55.0 °C(Predicted) | [density ]
1.550±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.10±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
JUN 68426, also known as Thalidomide 4'-ether-alkylC2-acid is a cereblon ligand with alkyl linker and terminal acid for onward chemistry. This product has no formal name at the moment. | [Uses]
Thalidomide-O-C2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. DOI:10.1016/j.cell.2020.07.024 |
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