| Identification | Back Directory | [Name]
(S,R,S)-AHPC-Me-C5-COOH | [CAS]
2376139-52-3 | [Synonyms]
(S,R,S)-AHPC-Me-C10-NH2
(2S,4R)-1-((S)-2-(11-Aminoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide | [Molecular Formula]
C34H53N5O4S | [MDL Number]
MFCD33029233 | [MOL File]
2376139-52-3.mol | [Molecular Weight]
627.88 |
| Chemical Properties | Back Directory | [Boiling point ]
850.9±65.0 °C(Predicted) | [density ]
1.145±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.97±0.40(Predicted) | [color ]
Light brown to orange |
| Hazard Information | Back Directory | [Description]
(S,R,S)-AHPC-Me-C10-NH2 is a E3 ligase ligand-linker conjugate that couples the VHL ligand to a 10 carbon alkane linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 | [Uses]
(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602)[1]. | [IC 50]
VHL | [References]
[1] Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019 Dec 12;62(23):10897-10911. DOI:10.1021/acs.jmedchem.9b01528 |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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