| Identification | Back Directory | [Name]
Thalidomide-O-amido-PEG1-(C1-?PEG)2-C2-NH2 | [CAS]
2435572-49-7 | [Synonyms]
Thalidomide-O-amido-PEG1-(C1-?PEG)2-C2-NH2
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 (TFA)
N-(2-(3-(3-(2-aminoethoxy)propoxy)propoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide | [Molecular Formula]
C27H35F3N4O11 | [MOL File]
2435572-49-7.mol | [Molecular Weight]
648.59 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. | [IC 50]
Cereblon | [References]
[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527 |
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