| Identification | Back Directory | [Name]
Thalidomide-O-PEG2-azide | [CAS]
2758431-90-0 | [Synonyms]
Thalidomide-O-PEG2-azide
4-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | [Molecular Formula]
C19H21N5O7 | [MOL File]
2758431-90-0.mol | [Molecular Weight]
431.41 |
| Hazard Information | Back Directory | [Uses]
Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs[1]. | [Biological Activity]
Thalidomide 4'-ether-PEG2-azide is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG2 linker with azide terminal ready for conjugation to a target protein ligand. | [storage]
Store at -20°C | [References]
[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. DOI:10.1038/nature13527 |
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| Company Name: |
R&D Systems, Inc
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| Tel: |
18003437475 18003437475 |
| Website: |
www.rndsystems.com |
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