| Identification | Back Directory | [Name]
Thalidomide-O-PEG1-azide | [CAS]
2758432-02-7 | [Synonyms]
Thalidomide-O-PEG1-azide
4-(2-(2-azidoethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | [Molecular Formula]
C17H17N5O6 | [MOL File]
2758432-02-7.mol | [Molecular Weight]
387.35 |
| Hazard Information | Back Directory | [Uses]
Thalidomide 4'-ether-PEG1-azide is the Thalidomide (HY-14658)-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4'-ether-PEG1-azide can be connected to the ligand for protein by a linker to form PROTACs[1]. | [Biological Activity]
Thalidomide 4'-ether-PEG1-azide is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG1 linker with azide terminal ready for conjugation to a target protein ligand. | [storage]
Store at -20°C | [References]
[1] Chen P, et al. α-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship. Bioorg Chem. 2021 Nov;116:105295. DOI:10.1016/j.bioorg.2021.105295 |
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