| Identification | Back Directory | [Name]
Thalidomide-O-amido-PEG4-azide | [CAS]
2411681-89-3 | [Synonyms]
Thalidomide-O-amido-PEG4-azide | [Molecular Formula]
C25H32N6O10 | [MDL Number]
MFCD32670309 | [MOL File]
2411681-89-3.mol | [Molecular Weight]
576.56 |
| Hazard Information | Back Directory | [Description]
Thalidomide-O-amido-PEG4-azide is a PROTAC linker that is reactive with alkyne or DBCO, BCN attached molecule via click chemistry, PEG space increase compound solubility. | [Uses]
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Thalidomide-O-amido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Cereblon | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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