| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]- | [CAS]
2488761-03-9 | [Synonyms]
Pom-8PEG
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)amino]- | [Molecular Formula]
C29H43N3O12 | [MOL File]
2488761-03-9.mol | [Molecular Weight]
625.66 |
| Chemical Properties | Back Directory | [Boiling point ]
786.6±60.0 °C(Predicted) | [density ]
1.301±0.06 g/cm3(Predicted) | [form ]
Viscous Liquid | [pka]
10.74±0.40(Predicted) | [color ]
Light green to green |
| Hazard Information | Back Directory | [Uses]
Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader[1]. | [IC 50]
Cereblon | [References]
[1] Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10(10):1943-1953. DOI:10.1016/j.apsb.2020.02.010 |
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