| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-[4-[[2-(2-aminoethoxy)ethyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, hydrochloride (1:2) | [CAS]
2624336-86-1 | [Synonyms]
2,6-Piperidinedione, 3-[4-[[2-(2-aminoethoxy)ethyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, hydrochloride (1:2) | [Molecular Formula]
C17H23ClN4O4 | [MOL File]
2624336-86-1.mol | [Molecular Weight]
382.85 |
| Hazard Information | Back Directory | [Uses]
Lenalidomide 4'-PEG1-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG1-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]. | [Biological Activity]
Lenalidomide 4'-PEG1-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG1 linker with terminal amine ready for conjugation to a target protein ligand. | [storage]
Store at -20°C | [References]
[1] Wang S, et al. Monofunctional intermediates for ligand-dependent target protein degradation. China, WO2017176958A1. 2017-10-12. |
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