| Identification | Back Directory | [Name]
PROTAC BRD4 Degrader-17 | [CAS]
2585561-49-3 | [Synonyms]
PROTAC BRD4 Degrader-17
N-({4-[(4-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}butyl)carbamoyl]phenyl}methyl)-4-[5-(2-hydroxypropan-2-yl)-2-phenoxyphenyl]-6-methyl-7-oxo-1H,6H,7H-pyrrolo[2,3-c]pyridine-2-carboxamide |
| Hazard Information | Back Directory | [Uses]
PROTAC BRD4 Degrader-17 (compound 13i) is a potent PROTAC BRD4 Degrader, with IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-17 significantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-17 significantly induces apoptosis in MV-4-11 cells[1]. | [IC 50]
BRD4 (BD2): 3.82 ± 0.0 nM (IC50); BRD4 (BD1): 29.54 ± 2. nM (IC50) | [References]
[1] Chen J, et al. Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold. Eur J Med Chem. 2022 Jun 5;236:114259. DOI:10.1016/j.ejmech.2022.114259 |
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