| Identification | Back Directory | [Name]
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride | [CAS]
NoCAS | [Synonyms]
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride | [Molecular Formula]
C25H24N4O4.ClH | [MOL File]
2748150-20-9.mol | [Molecular Weight]
480.94 |
| Hazard Information | Back Directory | [Uses]
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312)[1]. Lenalidomide-propargyl-C2-amido-Ph-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Cereblon | [References]
[1] Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466. DOI:10.1021/acs.jmedchem.8b00909 |
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