| Identification | Back Directory | [Name]
1-[4-[2-(4-Methoxyphenyl)-5-methyl-5H-pyrrolo[2,3-b]pyrazin-6-yl]-1-piperidinyl]ethanone | [CAS]
2759897-35-1 | [Synonyms]
Gcase activator 2
1-[4-[2-(4-Methoxyphenyl)-5-methyl-5H-pyrrolo[2,3-b]pyrazin-6-yl]-1-piperidinyl]ethanone | [Molecular Formula]
C21H24N4O2 | [MOL File]
2759897-35-1.mol | [Molecular Weight]
364.44 |
| Chemical Properties | Back Directory | [Boiling point ]
605.3±55.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
3.68±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM). Gcase activator 2 induces GCase dimerizatio (both K-type and V-type). And Gcase activator 2 has low metabolic clearance in human and mouse[1]. | [References]
[1] Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60(10):5436-5442. DOI:10.1002/anie.202013890 |
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