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2924573-90-8

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2924573-90-8 Structure

2924573-90-8 Structure
IdentificationBack Directory
[Name]

FX-909
[CAS]

2924573-90-8
[Synonyms]

FX-909
3-(5,7-difluoro-4-oxo-1,4-dihydroquinolin-2-yl)-4-(methylsulfonyl)benzonitrile
[Molecular Formula]

C17H10F2N2O3S
[MOL File]

2924573-90-8.mol
[Molecular Weight]

360.34
Chemical PropertiesBack Directory
[Boiling point ]

584.3±50.0 °C(predicted)
[density ]

1.55±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[solubility ]

Acetonitrile: Slightly soluble: 0.1-1 mg/ml
DMSO: Sparingly soluble: 1-10 mg/ml
Water: Slightly soluble: 0.1-1 mg/ml
[form ]

Solid
[pka]

-0.69±0.70(predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

FX-909 is a covalent peroxisome proliferator-activated receptor gamma (PPARG) inverse agonist. FX-909 can be used for the research of cancer[1].
[in vivo]

FX-909 (0.03-1 mg/kg; BID for 21 days) shows anticancer effects in UMUC9 UC xenograft mouse model[1].

[IC 50]

PPARγ
[References]

[1] Mertz J A, et al. Development of a surrogate tissue pharmacodynamic (PD) assay for clinical use with FX-909, a novel inhibitor of the urothelial luminal lineage transcription factor peroxisome proliferator-activated receptor gamma (PPARG). Cancer Research, 2023, 83(7_Supplement): 2802-2802.
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