| Identification | Back Directory | [Name]
ARUK2001607 | [CAS]
2924824-56-4 | [Synonyms]
Thieno[2,3-d]pyrimidin-4-amine, 6-methyl-N-[4-(methylsulfonyl)phenyl]- | [Molecular Formula]
C14H13N3O2S2 | [MOL File]
2924824-56-4.mol | [Molecular Weight]
319.4 |
| Chemical Properties | Back Directory | [Boiling point ]
571.057±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.429±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMSO: Soluble: =10 mg/ml | [form ]
Solid | [pka]
5.285±0.40(predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Uses]
ARUK2001607 is a selective phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ)?inhibitor with a Kd of 7.1 nM. ARUK2001607 shows high selectivity over other >150 kinases[1]. | [in vivo]
In Vivo Mouse Pharmacokinetics Parameters for Selected ARUK2001607 (15) (5 mg/kg; ip Administration)[1]
| T1/2 (h) | AUC (hr·ng/mL) | [plasma] at 0.5h (ng/mL) | [brain] at 0.5h (ng/g) | Kp | | ARUK2001607 (15) | 0.74 | 4520 | 2773 | 1590 | 0.58 |
| [References]
[1] Timothy P C Rooney, et al. The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. J Med Chem. 2022 Dec 14. DOI:10.1021/acs.jmedchem.2c01693 |
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| Company Name: |
TargetMol
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400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
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