| Identification | Back Directory | [Name]
Imidazo[1,2-a]pyridine-5-carbonitrile, 3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]-6-(methylamino)- | [CAS]
3033846-29-3 | [Synonyms]
Imidazo[1,2-a]pyridine-5-carbonitrile, 3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]-6-(methylamino)- | [Molecular Formula]
C23H24N6OS | [MOL File]
3033846-29-3.mol | [Molecular Weight]
432.54 |
| Chemical Properties | Back Directory | [density ]
1.33±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
9.52±0.20(predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
SIK-IN-1 (Compound 53) is an inhibitor for salt-inducible kinase (SIK), which inhibits SIK1, SIK2 and SIK3 with IC50s of 0.1, 0.4 and 1.5 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 4 nM in human macrophages[1]. | [References]
[1] Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1. |
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