| Identification | Back Directory | [Name]
N-[(4-methoxyphenyl)methyl]-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide | [CAS]
313987-85-8 | [Synonyms]
N-[(4-methoxyphenyl)methyl]-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide | [Molecular Formula]
C20H15F3N4O2S | [MOL File]
313987-85-8.mol | [Molecular Weight]
432.42 |
| Hazard Information | Back Directory | [Description]
Mycro1 is an inhibitor of the protein-protein interactions between the bHLHZip proteins c-Myc and Max. | [Uses]
Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation[1]. | [References]
[1] Kiessling A, et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol. 2006 Jul;13(7):745-51. DOI:10.1016/j.chembiol.2006.05.011
[2] Anke Kiessling, et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol. 2006 Jul;13(7):745-51. |
|
| Company Name: |
PHARMEKS Ltd.
|
| Tel: |
+7 (495) 702-9648 |
| Website: |
www.pharmeks.com |
|