| Identification | Back Directory | [Name]
5-thiophen-2-yl-N-(thiophen-2-ylmethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide | [CAS]
314049-21-3 | [Synonyms]
5-thiophen-2-yl-N-(thiophen-2-ylmethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide | [Molecular Formula]
C17H11F3N4OS2 | [MOL File]
314049-21-3.mol | [Molecular Weight]
408.421 |
| Hazard Information | Back Directory | [Description]
Mycro2 is an inhibitor of the protein-protein interactions between the bHLHZip proteins c-Myc and Max. | [Uses]
Mycro2 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 23 μM for the inhibition of Myc/Max DNA binding activity. Mycro2 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation[1]. | [References]
[1] Kiessling A, et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol. 2006 Jul;13(7):745-51. DOI:10.1016/j.chembiol.2006.05.011
[2] Anke Kiessling, et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol. 2006 Jul;13(7):745-51. |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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