| Identification | More | [Name]
4-Imidazolemethanol hydrochloride | [CAS]
32673-41-9 | [Synonyms]
1H-IMIDAZOL-4-YLMETHANOL
(1H-IMIDAZOL-4-YL)-METHANOL HCL
1H-IMIDAZOL-4-YLMETHANOL HYDROCHLORIDE
1H-IMIDAZOLE-4-METHANOL HCL
1H-IMIDAZOLE-4-YLMETHANOL HYDROCHLORIDE
4(5)-(HYDROXYMETHYL)IMIDAZOLE
4(5)-HYDROXYMETHYLIMIDAZOLE HYDROCHLORIDE
4-(HYDROXYMETHYL)-1H-IMIDAZOLE
4-(HYDROXYMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE
4-HYDROXYMETHYLIMIDAZOLE
4-(HYDROXYMETHYL)IMIDAZOLE HCL
4-(HYDROXYMETHYL)IMIDAZOLE HYDROCHLORIDE
4-IMIDAZOLEMETHANOL HYDROCHLORIDE
AKOS 85
RARECHEM AL BD 0762
TIMTEC-BB SBB004207
imidazol-4-ylmethanol hydrochloride
4-Hydromethylimidazole HCL
1H-Imidazole-4-methanol, monohydrochloride
4(5)-imidazolemethanol hydrochloride | [EINECS(EC#)]
251-150-0 | [Molecular Formula]
C4H7ClN2O | [MDL Number]
MFCD00266718 | [Molecular Weight]
134.56 | [MOL File]
32673-41-9.mol |
| Chemical Properties | Back Directory | [Appearance]
light yellow to beige or light brown crystalline | [Melting point ]
110 °C | [storage temp. ]
−20°C
| [solubility ]
water: soluble50mg/mL, clear to slightly hazy, colorless to yellow | [form ]
crystalline
| [color ]
off-white to yellow
| [Water Solubility ]
Soluble in water. | [BRN ]
3562041 | [Stability:]
Hygroscopic | [CAS DataBase Reference]
32673-41-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [F ]
3 | [Hazard Note ]
Irritant | [HS Code ]
29332900 |
| Hazard Information | Back Directory | [Chemical Properties]
light yellow to beige or light brown crystalline | [Uses]
4-Imidazolemethanol hydrochloride was used in the synthesis of imidazole-containing peptidomimetic inhibitors. | [Uses]
Synthesis of imidazole-containing peptidomimetic inhibitors.1 | [Synthesis]
A solvent mixture of acetonitrile and ethanol with a volume ratio of 2:1 was added to the reactor, and 100 mmol of 1,3-dihydroxyacetone and 200 mmol of formaldehyde were added sequentially and stirred until complete dissolution. Subsequently, 100 mmol of ceric ammonium nitrate was added as an oxidizing agent. The pH of the reaction system was adjusted to 10 by slow dropwise addition of sodium ethanolate solution at atmospheric pressure and 60 °C, and 15 mmol of catalyst was added. The reaction was stirred under this condition for 8 hours, and 4-hydroxymethylimidazole was obtained after completion of the reaction. To the reaction solution, concentrated hydrochloric acid was added dropwise to adjust the pH to 2, and the precipitate was collected by filtration. The solid was washed with saturated sodium chloride solution and subsequently recrystallized with ethanol. Finally, the product was dried under vacuum to obtain 4-hydroxymethylimidazole hydrochloride. The purity of the product was determined to be 98.2% and the yield was 87.5%. | [References]
[1] Patent: CN106349165, 2017, A. Location in patent: Paragraph 0016-0030 |
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