| Identification | Back Directory | [Name]
N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide | [CAS]
451491-47-7 | [Synonyms]
CTB >=98% (HPLC)
Histone Acetyltransferase Activator, CTB
N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide
Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-
Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem
HATs,Inhibitor,neurons,CTB,Apoptosis,MCF-7 cell,cancer,potent,HAT,autophagic flux,inhibit,Histone Acetyltransferase | [Molecular Formula]
C16H13ClF3NO2 | [MDL Number]
MFCD02356522 | [MOL File]
451491-47-7.mol | [Molecular Weight]
343.73 |
| Hazard Information | Back Directory | [Uses]
CTB has been used to study its apoptotic effects on P53 protein acetylation. | [Definition]
ChEBI:N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxybenzamide is a member of benzamides. | [Biological Activity]
CTPB was a first known small molecular activator of histone acetyltransferase p300. CTB is a simplified analog of CTPB with comparable or higher activity. The compound activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein.''Small molecule activators of H at such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatricneurodevelopmental and neurodegenerative diseases. | [IC 50]
CBP/p300 |
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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