| Identification | Back Directory | [Name]
Radiprodil | [CAS]
496054-87-6 | [Synonyms]
RGH 896
Radiprodil
RGH 896;RGH 896;RGH896
2-[4-(4-Fluorobenzyl)piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydrobenzoxazol-6-yl)acetamide
2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]-2-oxo-N-(2-oxo-3H-1,3-benzoxazol-6-yl)acetamide
1-Piperidineacetamide, N-(2,3-dihydro-2-oxo-6-benzoxazolyl)-4-[(4-fluorophenyl)methyl]-α-oxo- | [Molecular Formula]
C21H20FN3O4 | [MOL File]
496054-87-6.mol | [Molecular Weight]
397.4 |
| Chemical Properties | Back Directory | [Melting point ]
223-225 °C | [density ]
1.394±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 2mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL | [form ]
A solid | [pka]
8.62±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Radiprodil is used in the preparation of oximides as novel NR2B selective NMDA receptor anatagonists. | [in vivo]
Radiprodil could block NMDA currents in Mg2+ insensitive variants, with potencies similar to those obtained without Mg2+[3].
Radiprodil's potency is higher at pH 7.0 than at pH 7.6, suggesting that radiprodil may retain its ability to block glutamate-induced NMDA currents even under acidic conditions that manifest under long term seizures[3].
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