| Identification | More | [Name]
D-Gluconic acid copper(II) salt | [CAS]
527-09-3 | [Synonyms]
COPPER(+2)D-GLUCONATE
COPPER GLUCONATE
COPPER(II) D-GLUCONATE
COPPER(II) GLUCONATE
CUPRIC GLUCONATE
D-GLUCONIC ACID, COPPER(II) SALT
GLUCONIC ACID COPPER(II) SALT
GLUCONIC ACID COPPER SALT
bis(d-gluconato)-coppe
bis(d-gluconato-o1,o2)-coppe
bis(D-gluconato-O1,O2)-Copper
copper(2+)salt(2:1),d-gluconicaci
copper(2+)salt(2:1)d-gluconicaci
gluconicacid,copper(2+)salt
Chelates of copper gluconate
copper di-D-gluconate
Copper Gluconate USP26 FCCIV
Copper, bis(D-gluconato-.kappa.O1,.kappa.O2)-
COPPER GLUCONATE POWDER
COPPERGLUCONATE,FCC | [EINECS(EC#)]
208-408-2 | [Molecular Formula]
C12H22CuO14 | [MDL Number]
MFCD00075297 | [Molecular Weight]
453.84 | [MOL File]
527-09-3.mol |
| Chemical Properties | Back Directory | [Appearance]
blue crystalline powder | [Melting point ]
155-157 °C(lit.) | [Boiling point ]
673.6℃[at 101 325 Pa] | [density ]
1.777[at 20℃] | [vapor pressure ]
13.3Pa at 20℃ | [refractive index ]
16.5 ° (C=1, H2O) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Aqueous Acid (Slightly), Water (Sparingly, Sonicated) | [form ]
powder | [color ]
Light Blue to Blue | [Optical Rotation]
[α]26/D +15°, c = 1 in H2O | [Water Solubility ]
slightly soluble | [Merck ]
14,2640 | [Exposure limits]
ACGIH: TWA 1 mg/m3
NIOSH: IDLH 100 mg/m3; TWA 1 mg/m3 | [Stability:]
Hygrscopic | [Cosmetics Ingredients Functions]
SKIN PROTECTING
SKIN CONDITIONING | [Cosmetic Ingredient Review (CIR)]
Copper(II) gluconate (527-09-3) | [InChI]
1S/2C6H12O7.Cu/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1 | [InChIKey]
OCUCCJIRFHNWBP-IYEMJOQQSA-L | [SMILES]
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O[Cu]OC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO | [LogP]
-2.98 | [Uses]
copper gluconate is cited as having skin-conditioning and skinprotecting functions. | [CAS DataBase Reference]
527-09-3(CAS DataBase Reference) | [EPA Substance Registry System]
527-09-3(EPA Substance) |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
LZ5058000
| [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29181600 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 2
Skin Sens. 1B
STOT RE 2 | [Safety Profile]
When heated to
decomposition it emits acrid smoke and
irritating fumes. | [Hazardous Substances Data]
527-09-3(Hazardous Substances Data) |
| Questions And Answer | Back Directory | [Description]
Copper(II) gluconate is the copper salt of D-gluconic acid that is an organic acid. It can be used as a buffer for encapsulating some drugs into liposomes. Copper is an essential microelement for human beings and animals; it is needed to absorb ion from and gut and can help regulate blood pressure and heart rate. It is also a key component of multiple enzymes involved in many biochemical reactions. In this sense, the D-gluconic acid copper (II) salt can be used as a copper supplement to treat the copper deficiency induced anemia and nephrosis. It is also useful in the cancer chemotherapy being capable of enhancing the efficacy of the anticancer drug, disulfiram. | [References]
Dicko, Awa, et al. "Role of copper gluconate/triethanolamine in irinotecan encapsulation inside the liposomes." International Journal of Pharmaceutics 337.1(2007):219-228.
Ferris Iii, Frederick L, et al. "Nutritional supplement to treat macular degeneration.", EP1516542. 2009.
Georgewill Udeme Owunari, Siminialayi Iyeopu Minakiri. “Disulfiram and Copper gluconate in cancer chemotherapy: a review of the literature.” Cancer Research Journal 2.5(2014):88-92.
|
| Hazard Information | Back Directory | [Chemical Properties]
Copper(II) gluconate, Cu(C6H11O7)2, is a light blue to blue-green, crystalline material that is soluble in water and slightly soluble in ethanol. | [Definition]
ChEBI: Copper gluconate is an organic molecular entity. | [Preparation]
Copper(II) gluconate is prepared by the dissolution of copper(II) carbonate or copper(II) hydroxide in gluconic acid. It is used as a nutritional supplement for copper deficiency and as a component in oral deodorants. | [Flammability and Explosibility]
Notclassified |
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J & K SCIENTIFIC LTD.
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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China Langchem Inc.
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0086-21-58956006 |
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www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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Maya High Purity Chemicals
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+86 (573) 82222445 (0)18006601000 452520369 |
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277 |
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www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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