| Identification | Back Directory | [Name]
1H-Benzimidazole, 6-methoxy-2-(2-pyridinyl)- | [CAS]
63053-14-5 | [Synonyms]
AI457 HCl
AI-4-57 HCl
AI 4 57 HCl
1H-Benzimidazole, 6-methoxy-2-(2-pyridinyl)- | [Molecular Formula]
C13H11N3O | [MDL Number]
MFCD03773336 | [MOL File]
63053-14-5.mol | [Molecular Weight]
225.25 |
| Chemical Properties | Back Directory | [Melting point ]
133-134 °C(Solv: hexane (110-54-3); acetone (67-64-1)) | [Boiling point ]
459.9±43.0 °C(Predicted) | [density ]
1.268±0.06 g/cm3(Predicted) | [pka]
10.00±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
AI-4-57 Hydrochloride is a ligand to the CBF? portion of the CBF?-SMMHC fusion protein. AI-4-57 Hydrochloride inhibits its binding to the Runt domain of RUNX proteins, and is also a modest potency inhibitor of the binding of wildtype CBF? to the RUNX1 Runt domain. | [Uses]
AI-4-57 is an allosteric inhibitor for CBFβ SMMHC-RUNX1 (core binding factor β and the smooth-muscle myosin heavy chain) interaction with an IC50 of 22 μM[1]. | [References]
[1] Illendula A, et al., A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science. 2015 Feb 13;347(6223):779-84. DOI:10.1126/science.aaa0314 |
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