| Identification | More | [Name]
2-ACETYL-5-CHLOROTHIOPHENE | [CAS]
6310-09-4 | [Synonyms]
1-(5-CHLORO-2-THIENYL)ETHANONE
2-ACETYL-5-CHLOROTHIOPHENE
5-CHLORO-2-ACETYLTHIOPHENE
5-CHLORO-2-THIENYL METHYL KETONE
AKOS 93296
1-(5-chloro-2-thienyl)ethan-1-one
1-(5-Chloro-thiophen-2-yl)-ethanone
2-Acetyl-5-chlorthiophen
2-Chloro-5-acetylthiophene
5-Chlor-2-acetyl thiophen
5-chlor-2-acetylthiophen
5-Chloro-2-acetyl thiophen
5-chloro-2-acetylthiophen
BA 11044
ba11044
Ethanone, 1-(5-chloro-2-thienyl)-
Ethanone,1-(5-chloro-2-thienyl)-
Ketone, 5-chloro-2-thienyl methyl
ketone,5-chloro-2-thienylmethyl
2-Acetyl-5-chlorothiophene ,99% | [EINECS(EC#)]
228-630-3 | [Molecular Formula]
C6H5ClOS | [MDL Number]
MFCD00005444 | [Molecular Weight]
160.62 | [MOL File]
6310-09-4.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
46-49 °C (lit.) | [Boiling point ]
117-118 °C/17 mmHg (lit.) | [density ]
1.3240 (estimate) | [Fp ]
227 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Crystals or Crystalline Powder | [color ]
White to light yellow | [Sensitive ]
Light Sensitive | [Detection Methods]
HPLC | [BRN ]
113936 | [InChI]
InChI=1S/C6H5ClOS/c1-4(8)5-2-3-6(7)9-5/h2-3H,1H3 | [InChIKey]
HTZGPEHWQCRXGZ-UHFFFAOYSA-N | [SMILES]
C(=O)(C1SC(Cl)=CC=1)C | [CAS DataBase Reference]
6310-09-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
20/21/22 | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN2811 | [WGK Germany ]
3
| [RTECS ]
OB1745000
| [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Synthesis]
Example 8: In a 100 mL four-necked flask equipped with a stirrer, a condenser, a thermometer, and a dropping funnel, 5.9 g of activated white clay (a product of Nacalai Tesque, Inc.) and 25.5 g (0.25 mol) of acetic anhydride were added sequentially. The temperature of the reaction system was maintained at 45 °C to 55 °C and 29.6 g (0.25 mol) of 2-chlorothiophene was slowly added dropwise over 1 h in this temperature range. After the dropwise addition was completed, the reaction was continued with stirring at 50 °C for 72 hours. Upon completion of the reaction, the activated white clay was removed by filtration to give a dark brown filtrate. Subsequently, unreacted 2-chlorothiophene, acetic anhydride and the by-product acetic acid were removed from the filtrate by distillation, resulting in 20.9 g (0.13 mol) of 2-acetyl-5-chlorothiophene. | [References]
[1] Patent: EP1695972, 2006, A1. Location in patent: Page/Page column 7
[2] Journal of the American Chemical Society, 1947, vol. 69, p. 3093,3095
[3] Journal of Organic Chemistry, 1948, vol. 13, p. 729,732
[4] Org. Synth. Coll. Vol. IV, <1963> 980,
[5] Journal of the American Chemical Society, 1947, vol. 69, p. 1014 |
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