| Identification | Back Directory | [Name]
Br-PEG6-bromide | [CAS]
72713-23-6 | [Synonyms]
Br-PEG6-Br
Br-PEG6-bromide
Br-PEG6-CH2CH2Br
1,2-Bis-{2-[2-(2-bromo-ethoxy)-ethoxy]-ethoxy}-ethane | [Molecular Formula]
C14H28Br2O6 | [MDL Number]
MFCD30536166 | [MOL File]
72713-23-6.mol | [Molecular Weight]
452.18 |
| Hazard Information | Back Directory | [Description]
Bromo-PEG6-bromide is a PEG linker containing two bromide groups. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Bromo-PEG6-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Mulyana Y, et al. Oligonuclear polypyridylruthenium(II) complexes incorporating flexible polar and non-polar bridges: synthesis, DNA-binding and cytotoxicity. Dalton Trans. 2011 Feb 21;40(7):1510-23. DOI:10.1039/c0dt01250e
[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
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