| Identification | Back Directory | [Name]
Bromo-PEG1-CH2CO2H | [CAS]
1135131-50-8 | [Synonyms]
CAS_1135131-50-8
Bromo-PEG1-CH2CO2H
Bromo-PEG7-CH2CO2H
Bromo-PEG1-CH2COOH
Bromo-PEG1-acetic acid
(2-Bromo-ethoxy)-acetic acid
2-(2-Bromoethoxy)acetic acid
Acetic acid, 2-(2-bromoethoxy)-
Bromo-PEG1-acetic acid,Bromo-PEG1-CH2CO2H | [Molecular Formula]
C4H7BrO3 | [MDL Number]
MFCD20637665 | [MOL File]
1135131-50-8.mol | [Molecular Weight]
183 |
| Chemical Properties | Back Directory | [Boiling point ]
316.4±17.0 °C(Predicted) | [density ]
1.683±0.06 g/cm3(Predicted) | [form ]
Solid-Liquid Mixture | [pka]
3.31±0.10(Predicted) | [color ]
Colorless to off-white |
| Hazard Information | Back Directory | [Description]
Bromo-PEG1-CH2CO2H is a PEG linker containing a bromide group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Bromo-PEG1-CH2COOH is a PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Christopher Michael Semko, et al. C26-linked rapamycin analogs as mtor inhibitors. WO2019212991A1. |
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