| Identification | Back Directory | [Name]
Quinofumelin | [CAS]
861647-84-9 | [Synonyms]
Quinofumelin
Quinoline, 3-(4,4-difluoro-3,4-dihydro-3,3-dimethyl-1-isoquinolinyl)- | [Molecular Formula]
C20H16F2N2 | [MOL File]
861647-84-9.mol | [Molecular Weight]
322.35 |
| Hazard Information | Back Directory | [Production Methods]
Quinofumelin is prepared through a short, convergent synthetic sequence that builds its fused quinoline–isoquinolinone framework. It begins with the construction of the difluoro substituted dihydroisoquinolinone fragment via cyclisation of a suitably substituted anilide under dehydrating conditions. In parallel, a halogenated quinoline precursor is generated through electrophilic substitution on a quinoline core. These two key fragments are then joined through a nucleophilic aromatic substitution that installs the isoquinolinone moiety onto the quinoline ring. Final steps involve purification, salt removal, and crystallisation to yield technical grade quinofumelin suitable for formulation. | [Mechanism of action]
Inhibits DHODH II (dihydroorotate dehydrogenase II) | [Pesticide Type]
Fungicide |
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