| Identification | More | [Name]
N-Acetylanthranilic acid | [CAS]
89-52-1 | [Synonyms]
2-ACETAMIDOBENZOIC ACID
2-ACETYLAMINOBENZOIC ACID
AKOS 92175
N-ACETYL-1-AMINO-2-CARBOXYBENZENE
N-ACETYL-2-AMINO BENZOIC ACID
N-ACETYL-2-CARBOXYANILINE
N-ACETYLANTHRANILIC ACID
O-ACETAMIDOBENZOIC ACID
O-ACETAMIDOPHENYLCARBOXYLIC ACID
O-ACETAMINOBENZOIC ACID
O-ACETAMINOPHENYLCARBOXYLIC ACID
O-ACETYLAMINOBENZOIC ACID
O-ACETYLAMINOPHENYLCARBOXYLIC ACID
2-(acetylamino)-benzoicaci
2-carboxyacetanilide
acetylanthranilicacid
Lappaconiticacid
n-acetylaminobenzoicacid
n-acetyl-anthranilicaci
n-acetylanthranillicacid | [EINECS(EC#)]
201-914-4 | [Molecular Formula]
C9H9NO3 | [MDL Number]
MFCD00002423 | [Molecular Weight]
179.17 | [MOL File]
89-52-1.mol |
| Chemical Properties | Back Directory | [Appearance]
solid | [Melting point ]
184-187 °C(lit.) | [Boiling point ]
311.69°C (rough estimate) | [density ]
1.2822 (rough estimate) | [refractive index ]
1.5600 (estimate) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
pK1: 3.63 (25°C) | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents. | [Water Solubility ]
slightly soluble | [BRN ]
880371 | [CAS DataBase Reference]
89-52-1(CAS DataBase Reference) | [EPA Substance Registry System]
89-52-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
CB2455000
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29242300 | [Toxicity]
LD50 orl-mus: 1114 mg/kg FRPSAX 38,847,83 |
| Hazard Information | Back Directory | [Description]
N-Acetylanthranilic acid (Item No. 18707) is an analytical reference standard categorized as a precursor in the synthesis of methaqualone (Item Nos. 20283 | 9000636).1 N-Acetylanthranilic Acid is regulated as a List I chemical in the United States. This product is intended for research and forensic applications.WARNING This product is not for human or veterinary use. | [Chemical Properties]
solid | [Uses]
N-Acetylanthranilic acid is a pharmaceutical intermediate used in the production of the non-barbiturate hypnotic drug methaqualone. | [Definition]
ChEBI: An amidobenzoic acid consisting of anthranilic acid carrying an N-acetyl group. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 46, p. 4614, 1981 DOI: 10.1021/jo00335a075
Tetrahedron Letters, 23, p. 4473, 1982 DOI: 10.1016/S0040-4039(00)85631-2 | [Safety Profile]
Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx. | [Purification Methods]
Wash the acid with distilled H2O and recrystallise it from aqueous AcOH, dry it and recrystallise again from EtOAc. Also recrystallise it from water or EtOH. UV: max 221, 252 and 305nm (EtOH). The amide crystallises from aqueous EtOH and has m 186-187o and max 218, 252 and 301nm. [Chattaway J Chem Soc 2495 1931, Walker J Am Chem Soc 77 6698 1955, Beilstein 14 H 337, 14 I 540, 14 II 219, 14 III 922.] |
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