| Identification | More | [Name]
Salmeterol xinafoate | [CAS]
94749-08-3 | [Synonyms]
rial
SN 408
Siduomi
GR 3343G
Serevent
GR-33343G
Salmetedur
Serevent Diskus
GR 33343X XINAFOATE
SalMeterol Solution
SALMETEROL XINAFOATE
SALMETEROL XINAFONATE
salMaterol xinafoate
Salmaterol Xinafloate
JigMei acid salMeterol
SalMeterol Hydroxynapthoate
SalMeterol Xinafoate Aerosol
Salmeterol hydroxynaphthoate
Salmeterol Xinafoate (150 mg)
SalMeterol-d12 Xinafoate salt
AtracuriuM Besilate IMp. J (EP)
Salmeterol, 1-Hydroxy-2-naphthoate
(+/-) 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]M-ETHYL]-1,3-BENZENEDIMETHANOL XINAFOATE
(±)-4-Hydroxy-alpha1-[[[6-(4-phenylbutoxy)hexy])amino]methyl]-1,3-benzenedimethanol xinafoate
4-(1-Hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol 1-hydroxy-2-naphtho
2-(Hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol 1-hydroxy-2-naphthoate
4-(1-Hydroxy-2-((6-(4-phenylbutoxy)hexyl)aMino)ethyl)-2-(hydroxyMethyl)phenol 1-hydroxy-2-naphthoate
4-Hydroxy-alpha-({[6-(4-phenylbutoxy)hexyl]amino}methyl)-1,3-benzenedimethanol xinafoate, GR 33343X xinafoate
4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]aMino]Methyl]-1,3-benzenediMethanol 1-Hydroxy-2-naphthalenecarboxylic Acid
GR 33343X xinafoate, (±) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol xinafoate
Salmeterol Xinafoate
2-(Hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol 1-hydroxy-2-naphthoate
4-hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol with 1-hydroxy-2-naphthalenecarboxylic acid(1:1)
1,3-Benzenedimethanol, 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-, 1-hydroxy-2-naphthalenecarboxylate (salt) (9CI)
1,3-Benzenedimethanol, 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-, (+-)-, 1-hydroxy-2-naphthalenecarboxylate (salt)
2-Naphthalenecarboxylic acid, 1-hydroxy-, compd. with (+-)-4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (1:1)
2-Naphthalenecarboxylic acid, 1-hydroxy-, compd. with 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (1:1) (9CI) | [Molecular Formula]
C36H45NO7 | [MDL Number]
MFCD00897708 | [Molecular Weight]
603.74 | [MOL File]
94749-08-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
137-138°C | [storage temp. ]
2-8°C | [solubility ]
H2O: slightly soluble
| [form ]
solid
| [color ]
white
| [Usage]
A ?-Adrenergic agonist. Structural analog of albuterol | [Merck ]
14,8337 | [Major Application]
pharmaceutical (small molecule) | [InChIKey]
XTZNCVSCVHTPAI-UHFFFAOYSA-N | [SMILES]
C12C=CC=CC=1C(O)=C(C(=O)O)C=C2.C1(C(O)CNCCCCCCOCCCCC2C=CC=CC=2)=CC=C(O)C(CO)=C1 | [CAS DataBase Reference]
94749-08-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P280-P271 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
QJ1970500 | [HS Code ]
2922504500 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Description]
Salmeterol hydroxynaphthoate is a new long-acting β2-selective adrenoceptor agonist
introduced as a bronchodilator for the treatment of reversible airway obstruction in asthma
and chronic bronchitis. It has bronchodilatory activity as intense and four times longerlasting
than equivalent doses of salbutamol. Salmeterol hydroxynaphthoate is reported to
be the first bronchodilator with significant anti-inflammatory activity and hence could
complement prophylactic corticosteroid therapy. | [Chemical Properties]
White to Off-White Solid | [Originator]
Glaxo (United Kingdom) | [Uses]
A ?-Adrenergic agonist. Structural analog of albuterol | [Uses]
A β2-Adrenergic agonist. Structural analog of Albuterol (A514500). | [Uses]
Bronchodilator; Beta2-adrenoceptor agonist | [Uses]
Smooth wheezing anti-inflammatory | [Application]
Salmeterol xinafoate is a potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM) that displays bronchodilator actions. Unlike other β2- adrenoceptor agonists, Salmeterol binds to exo-site domain of β2-AR receptors, producing a slow onset of action and prolonged activation. Clinically used for the treatment of asthma and chronic obstructive pulmonary disease(COPD). | [Definition]
ChEBI: Salmeterol xinafoate is a naphthoic acid. | [Brand name]
Serevent (GlaxoSmithKline). | [Biochem/physiol Actions]
β2-adrenoceptor agonist. | [storage]
Store at -20°C | [References]
[1] PANAYIOTIS A. PROCOPIOU . The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating a urea group[J]. Bioorganic & Medicinal Chemistry, 2011, 19 20: Pages 6026-6032. DOI: 10.1016/j.bmc.2011.08.043
[2] D.I. BALL. Salmeterol, a novel, long-acting β2-adrenoceptor agonist: characterization of pharmacological activity in vitro and in vivo[J]. British Journal of Pharmacology, 1991, 104 3: 665-671. DOI: 10.1111/j.1476-5381.1991.tb12486.x
[3] BASAK ISIN. Identifying ligand binding conformations of the β2-adrenergic receptor by using its agonists as computational probes.[J]. ACS Applied Bio Materials, 2012: e50186. DOI: 10.1371/journal.pone.0050186 |
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