| Identification | More | [Name]
2-Methoxy-4-nitroaniline | [CAS]
97-52-9 | [Synonyms]
1-AMINO-2-METHOXY-4-NITROBENZENE
2-Amino-5-nitroanis01
2-AMINO-5-NITROANISOLE
2-METHOXY-4-NITROANILINE
4-NITRO-2-METHOXYANILINE
4-NITRO-O-ANISIDINE
5-NITRO-2-AMINOANISOLE
5-NITRO-2-ANISIDINE
AZOIC DIAZO COMPONENT 5
AZOIC DIAZO NO 5
BRENTAMINE
CI 37125
FAST RED B
FAST RED BASE B
FAST RED B BASE
KERNECHTROT SALT B
RED B ASE
RED B BASE
RED R BASE
2-Amino-1-methoxy-5-nitrobenzene | [EINECS(EC#)]
202-588-6 | [Molecular Formula]
C7H8N2O3 | [MDL Number]
MFCD00007363 | [Molecular Weight]
168.15 | [MOL File]
97-52-9.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow to orange crystalline powder | [Melting point ]
140-142 °C(lit.)
| [Boiling point ]
337.07°C (rough estimate) | [density ]
1,211 g/cm3 | [refractive index ]
1.6010 (estimate) | [storage temp. ]
Store below +30°C. | [solubility ]
0.2g/l | [form ]
Crystalline Powder | [pka]
1.02±0.10(Predicted) | [color ]
Yellow to orange | [PH]
6.2 (0.2g/l, H2O, 20℃) | [Water Solubility ]
slightly soluble | [BRN ]
879619 | [InChI]
1S/C7H8N2O3/c1-12-7-4-5(9(10)11)2-3-6(7)8/h2-4H,8H2,1H3 | [InChIKey]
GVBHRNIWBGTNQA-UHFFFAOYSA-N | [SMILES]
COc1cc(ccc1N)[N+]([O-])=O | [CAS DataBase Reference]
97-52-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenamine, 2-methoxy-4-nitro-(97-52-9) | [EPA Substance Registry System]
97-52-9(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS07,GHS08,GHS09 | [Signal word ]
Warning | [Hazard statements ]
H302-H351-H411 | [Precautionary statements ]
P202-P264-P270-P273-P301+P312-P308+P313 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
2
| [RTECS ]
BZ7170000
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29222900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Chronic 2
Carc. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow to orange crystalline powder | [Uses]
2-Methoxy-4-nitroaniline is used as a photometric reagent for the determination of ethinylestradiol (ETE), a semi-synthetic estrogen that is widely used in oral contraceptives. | [General Description]
2-Methoxy-4-nitroaniline is an important inducer of CYP1A2 owing to its small molecular size. | [Flammability and Explosibility]
Nonflammable | [Biochem/physiol Actions]
The metabolism of 2-methoxy-4-nitroaniline (MNA) occurs via the hydroxylation of the phenyl ring to form 6-hydroxy MNA in Harlan Sprague Dawley rats and B6C3F(1)/N mice. | [Solubility in organics]
The change trend of the solubility magnitude in different monosolvents from high to low was as follows: N-methylpyrrolidone (NMP) > dimethyl sulfoxide (DMSO) > 1,4-dioxane > ethyl acetate > acetonitrile > ethanol > methanol > n-propanol > isopropanol > ethylene glycol (EG) > n-butanol > water[1]. | [References]
[1] Bao Y, et al. 2-Methoxy-4-nitroaniline Solubility in Several Monosolvents: Measurement, Correlation, and Solvent Effect Analysis. Journal of Chemical & Engineering Data, 2020; 65: 757–765.
[2] Degawa M, et al.2-Methoxy-4-nitroaniline is a selective inducer of cytochrome P450IA2 (CYP1A2) in rat liver. Cancer Letters, 1995; 96: 95-98.
[3] Ravikumar C, et al. Electronic absorption and vibrational spectra and nonlinear optical properties of 4-methoxy-2-nitroaniline. Physical Chemistry Chemical Physics, 2010; 12: 9452-9460. |
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