1-N-BOC-4-哌啶乙酸甲酯
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- CAS号:
- 175213-46-4
- 英文名:
- METHYL 1-BOC-4-PIPERIDINEACETATE
- 英文别名:
- METHYL 1-BOC-4-PIPERIDINEACETATE;Methyl N-Boc-4-piperidineacetate;Methyl N-BOC-piperidine-4-acetate;Methyl 1-N-Boc-4-piperidineacetate;1-Boc-4-Piperidine acetate methyl ester;N-BOC-4-PIPERIDINEACETIC ACID METHYL ESTER;1-Boc-4-Piperidine acetic acid methyl ester;Methyl 1-Boc-4-piperidine acetate - [M12265];Methyl (piperidin-4-yl)acetate, N-BOC protected;2-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}propanoate
- 中文名:
- 1-N-BOC-4-哌啶乙酸甲酯
- 中文别名:
- N-Boc-4-哌啶乙酸甲酯;1-BOC-4-哌啶乙酸甲酯;甲酯N-BOC-哌啶-4-乙酸;N-BOC-哌啶-4-乙酸甲酯;11-BOC-4-哌啶乙酸甲脂;1-N-BOC-4-哌啶乙酸甲酯;1-N-BOC-4-哌啶乙酸甲酯;N-叔丁氧羰基-4-哌啶乙酸甲酯
- CBNumber:
- CB2491392
- 分子式:
- C13H23NO4
- 分子量:
- 257.33
- MOL File:
- 175213-46-4.mol
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1-N-BOC-4-哌啶乙酸甲酯化学性质
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沸点:
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323.1±15.0 °C(Predicted)
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密度:
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1.062±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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酸度系数(pKa):
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-1.88±0.40(Predicted)
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外观:
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Colorless to light yellow Liquid
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CAS 数据库:
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175213-46-4
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1-N-BOC-4-哌啶乙酸甲酯性质、用途与生产工艺
生产方法
以4-(2-甲氧基-2-氧代亚乙基)哌啶-1-甲酸叔丁酯为原料合成N-Boc-4-哌啶乙酸甲酯的一般步骤：将1-叔丁氧基羰基-4-[(甲氧基羰基)亚甲基]哌啶（875 mg）溶于乙醇（10 mL）中，向该溶液中加入10%钯碳催化剂（约50%水含量，730 mg）。将反应混合物在室温及常压下进行催化氢化反应3天。反应完成后，通过过滤去除催化剂，随后在减压条件下蒸馏除去溶剂，得到目标产物N-Boc-4-哌啶乙酸甲酯（871 mg，收率99%）。产物经1H-NMR（CDCl3）表征：δ 1.16（2H，m），1.45（9H，s），1.65（2H，m），1.93（1H，m），2.25（2H，d，J = 6.8 Hz），2.72（2H，br），3.68（3H，s），4.08（2H，br）。质谱（FAB）分析显示m/z：258（M + H）+。
参考文献：
[1] Patent: EP1104754, 2001, A1
[2] Patent: EP1577302, 2005, A1. Location in patent: Page/Page column 121-122
[3] Patent: US2006/94707, 2006, A1. Location in patent: Page/Page column 43
[4] Patent: US2007/259850, 2007, A1. Location in patent: Page/Page column 79
[5] Patent: WO2011/123232, 2011, A1. Location in patent: Page/Page column 9
1-N-BOC-4-哌啶乙酸甲酯
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | XW0217073753806 | 4-(2-甲氧基-2-氧代乙基)哌啶-1-羧酸苄酯
Benzyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate | | 100g | 5592元 |
| 2025/05/22 | XW0217521346405 | N-BOC-4-哌啶乙酸甲酯 | 175213-46-4 | 100G | 659元 |
175213-46-4, 1-N-BOC-4-哌啶乙酸甲酯 相关搜索:
- Carboxes
- blocks
- Amines
- pharmacetical
- 哌啶
- 1-N-BOC-4-哌啶乙酸甲酯
- 甲酯N-BOC-哌啶-4-乙酸
- N-BOC-哌啶-4-乙酸甲酯
- 1-BOC-4-哌啶乙酸甲酯
- 1-N-BOC-4-哌啶乙酸甲酯
- 11-BOC-4-哌啶乙酸甲脂
- N-Boc-4-哌啶乙酸甲酯
- N-叔丁氧羰基-4-哌啶乙酸甲酯
- 175213-46-4
- Methyl 1-Boc-4-piperidine acetate - [M12265]
- Methyl 1-[(1,1-dimethylethoxy)carbonyl]-4-piperidineacetate
- Methyl N-Boc-4-piperidineacetate
- 4-Piperidineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
- Methyl 1-N-Boc-4-piperidineacetate
- benzyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate
- ert-butyl 4-(2-Methoxy-2-oxoethyl)piperidine-1-carboxylate
- 2-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}propanoate
- Methyl N-BOC-piperidine-4-acetate
- tert-butyl 4-((methoxycarbonyl)methyl)piperidine-1-carboxylate
- 1-Boc-4-Piperidine acetic acid methyl ester
- 1-Boc-4-Piperidine acetate methyl ester
- tert-butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate
- Methyl N-Boc-4-piperidineacetate
Methyl 1-Boc-4-piperidineacetate
4-((Methoxycarbonyl)methyl)piperidine-1-carboxylic acid tert-butyl ester
- t-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate
- METHYL 1-BOC-4-PIPERIDINEACETATE
- N-BOC-4-PIPERIDINEACETIC ACID METHYL ESTER
- Methyl (piperidin-4-yl)acetate, N-BOC protected