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METHYL 1-BOC-4-PIPERIDINEACETATE

METHYL 1-BOC-4-PIPERIDINEACETATE structure

CAS No.: 175213-46-4

Chemical Name:: METHYL 1-BOC-4-PIPERIDINEACETATE

Synonyms: METHYL 1-BOC-4-PIPERIDINEACETATE;Methyl N-Boc-4-piperidineacetate;Methyl N-BOC-piperidine-4-acetate;Methyl 1-N-Boc-4-piperidineacetate;1-Boc-4-Piperidine acetate methyl ester;N-BOC-4-PIPERIDINEACETIC ACID METHYL ESTER;1-Boc-4-Piperidine acetic acid methyl ester;Methyl 1-Boc-4-piperidine acetate - [M12265];Methyl (piperidin-4-yl)acetate, N-BOC protected;2-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}propanoate

CBNumber:: CB2491392

Molecular Formula:: C13H23NO4

Molecular Weight:: 257.33

MDL Number:: MFCD01632529

MOL File:: 175213-46-4.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:45

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METHYL 1-BOC-4-PIPERIDINEACETATE Properties

Boiling point	323.1±15.0 °C(Predicted)
Density	1.062±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	-1.88±0.40(Predicted)
Appearance	Colorless to light yellow Liquid
CAS DataBase Reference	175213-46-4

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P271-P261-P280
HS Code	29333990

METHYL 1-BOC-4-PIPERIDINEACETATE price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M295748	Methyl1-Boc-4-piperidineacetate	175213-46-4	500mg	$75	2021-12-16	Buy
Biosynth Carbosynth	FB140306	tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate	175213-46-4	1g	$60	2021-12-16	Buy
Synthonix	M12265	Methyl1-Boc-4-piperidineacetate 95+%	175213-46-4	1g	$30	2021-12-16	Buy
Synthonix	M12265	Methyl1-Boc-4-piperidineacetate 95+%	175213-46-4	5g	$40	2021-12-16	Buy
Biosynth Carbosynth	FB140306	tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate	175213-46-4	2g	$104	2021-12-16	Buy

Product number	Packaging	Price	Buy
M295748	500mg	$75	Buy
FB140306	1g	$60	Buy
M12265	1g	$30	Buy
M12265	5g	$40	Buy
FB140306	2g	$104	Buy

METHYL 1-BOC-4-PIPERIDINEACETATE Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

Methyl 1-Boc-4-piperidineacetate is used as a pharmaceutical intermediate. It can be used in the preparation of intranasal pharmaceutical compositions of CGRP inhibitors for the treatment of migraine.

Synthesis

tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate

169206-65-9

175213-46-4

General procedure for the synthesis of methyl N-Boc-4-piperidineacetate from tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate: 1-tert-butoxycarbonyl-4-[(methoxycarbonyl)methylidene]piperidine (875 mg) was dissolved in ethanol (10 mL), to which 10% of palladium-carbon catalyst (~50% water content, 730 mg) was added. The reaction mixture was subjected to catalytic hydrogenation at room temperature and at atmospheric pressure for 3 days. Upon completion of the reaction, the catalyst was removed by filtration and the solvent was subsequently removed by distillation under reduced pressure to afford the target product methyl N-Boc-4-piperidineacetate (871 mg, 99% yield). The product was characterized by 1H-NMR (CDCl3): δ 1.16 (2H, m), 1.45 (9H, s), 1.65 (2H, m), 1.93 (1H, m), 2.25 (2H, d, J = 6.8 Hz), 2.72 (2H, br), 3.68 (3H, s), 4.08 (2H, br). Mass spectrometry (FAB) analysis showed m/z: 258 (M + H)+.

References

[1] Patent: EP1104754, 2001, A1
[2] Patent: EP1577302, 2005, A1. Location in patent: Page/Page column 121-122
[3] Patent: US2006/94707, 2006, A1. Location in patent: Page/Page column 43
[4] Patent: US2007/259850, 2007, A1. Location in patent: Page/Page column 79
[5] Patent: WO2011/123232, 2011, A1. Location in patent: Page/Page column 9

METHYL 1-BOC-4-PIPERIDINEACETATE Preparation Products And Raw materials

Raw materials

tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate Di-tert-butyl dicarbonate Methyl 4-piperidineacetate Hydrogen Ethanol

Preparation Products

METHYL 1-BOC-4-PIPERIDINEACETATE Suppliers

Global( 145)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	9029	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
Zjartschem	+86-571 87238903	jocelynpan@zjarts.com	CHINA	988	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12222	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
Zjartschem	58
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Zhengzhou Alfa Chemical Co.,Ltd	58

View Lastest Price from METHYL 1-BOC-4-PIPERIDINEACETATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-07-08	tert-butyl 4-(2-methoxy-2-oxo-ethyl)piperidine-1-carboxylate 175213-46-4	US $2.20-8.80 / KG	1KG	99%	g-kg-tons	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2019-07-06	METHYL 1-BOC-4-PIPERIDINEACETATE 175213-46-4	US $1.00 / KG	1KG	98%	1ton	Career Henan Chemical Co

tert-butyl 4-(2-methoxy-2-oxo-ethyl)piperidine-1-carboxylate
175213-46-4
US $2.20-8.80 / KG
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

METHYL 1-BOC-4-PIPERIDINEACETATE
175213-46-4
US $1.00 / KG
98%
Career Henan Chemical Co

METHYL 1-BOC-4-PIPERIDINEACETATE Spectrum

METHYL 1-BOC-4-PIPERIDINEACETATE(175213-46-4)¹HNMR

175213-46-4(METHYL 1-BOC-4-PIPERIDINEACETATE)Related Search:

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(S)-BENZYLOXYCARBONYL-N'-T-BUTYLOXYCARBONYL-4-PIPERIDYLGLYCINE METHYL ESTER (S)-4-(AMINO-METHOXYCARBONYL-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-BENZYLOXYCARBONYL-N'-T-BUTYLOXYCARBONYL-4-PIPERIDYLGLYCINE METHYL ESTER 2-BROMO-2- (1-TERT-BUTOXYCARBONYL-PIPERIDIN-4-YL)-MALONIC ACID DIMETHYL ESTER (R)-4-(AMINO-METHOXYCARBONYL-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

2-(1-TERT-BUTOXYCARBONYL-PIPERIDIN-4-YL)-MALONIC ACID DIMETHYL ESTER Methyl 2-benzyl-8-Boc-2,8-diaza-spiro[4.5]decane-4-carboxylate TERT-BUTYL 4-((ETHOXYCARBONYL)METHYL)PIPERIDINE-1-CARBOXYLATE

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Methyl (piperidin-4-yl)acetate, N-BOC protected N-BOC-4-PIPERIDINEACETIC ACID METHYL ESTER METHYL 1-BOC-4-PIPERIDINEACETATE t-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate Methyl N-Boc-4-piperidineacetate Methyl 1-Boc-4-piperidineacetate 4-((Methoxycarbonyl)methyl)piperidine-1-carboxylic acid tert-butyl ester tert-butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate 1-Boc-4-Piperidine acetate methyl ester 1-Boc-4-Piperidine acetic acid methyl ester tert-butyl 4-((methoxycarbonyl)methyl)piperidine-1-carboxylate Methyl N-BOC-piperidine-4-acetate 2-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}propanoate ert-butyl 4-(2-Methoxy-2-oxoethyl)piperidine-1-carboxylate benzyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate Methyl 1-N-Boc-4-piperidineacetate 4-Piperidineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester Methyl N-Boc-4-piperidineacetate Methyl 1-[(1,1-dimethylethoxy)carbonyl]-4-piperidineacetate Methyl 1-Boc-4-piperidine acetate - [M12265] 175213-46-4 pharmacetical Amines blocks Carboxes