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Boc-His(Trt)-OH

Boc-His(Trt)-OH Struktur
32926-43-5
CAS-Nr.
32926-43-5
Englisch Name:
Boc-His(Trt)-OH
Synonyma:
BOC-HIS(TRT)-OH;Boc-His(trt);His(Trt)-OH;BOC-L-HIS(TRT)-OH;Boc-L-His(Trt);Impurity HA-1;N-Boc-His(Trt)-OH;(S)-L-Boc-his(trt)-oh;Boc-His(Trt)-OH, >=98%;BOC-N-IM-TRITYL-L-HISTIDINE
CBNumber:
CB0342634
Summenformel:
C30H31N3O4
Molgewicht:
497.59
MOL-Datei:
32926-43-5.mol
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Boc-His(Trt)-OH Eigenschaften

Schmelzpunkt:
~130 °C (dec.)
alpha 
12.5 º (C=1% IN MEOH)
Siedepunkt:
667.5±55.0 °C(Predicted)
Dichte
1.16±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit
DMSO (Slightly), Methanol (Sparingly)
pka
3.17±0.10(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
Optische Rotation
[α]20/D +12.5±1.0°, c = 1% in methanol
BRN 
732035
Major Application
peptide synthesis
InChIKey
OYXZPXVCRAAKCM-SANMLTNESA-N
SMILES
C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)NC(OC(C)(C)C)=O
CAS Datenbank
32926-43-5(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  3
HS Code  29224999
Speicherklasse 11 - Combustible Solids
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Boc-His(Trt)-OH Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White to off white powder

Verwenden

Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.

Verwenden

Boc-His(Trt)-OH is a histidine derivative. Its a protected histidine derivative for only the critical coupling step. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA.

synthetische

The benzyl 2-tert-butoxycarbonylamino-3-(1-trimethylimidazol-4-yl)propionate was dissolved in methanol (20 mL), and potassium hydroxide was added to the reaction system. The reaction system was stirred for 1 h after THF was added to the reaction system. The solvent is removed under vacuum depressurization, and the mixture is then extracted with water and Et2O. Separate the two phases and acidify the aqueous layer with dilute HCl, extract it with Et2O, combine all the ether organic layer and wash it with water and saline, dry the organic layer with anhydrous magnesium sulfate, filter to remove the solvent, and concentrate the filtrate under vacuum under reduced pressure to obtain Boc-His(Trt)-OH.

Application

N-Boc-N'-Trityl-L-histidine (Boc-His(Trt)-OH) can be used as an intermediate in biochemistry and medicinal chemistry and can be used in the synthesis of peptide drug molecules, vitamins, and molecules with specific biologically active functions. In organic synthesis transformation, the carboxyl group in N-Boc-N'-trityl-L-histidine can undergo corresponding condensation reactions with amine compounds to obtain the corresponding amide products; in addition, in dithionyl chloride Under the action of N-Boc-N'-trityl-L-histidine, intramolecular dehydration cyclization reaction can be performed to obtain cyclic amide derivatives.

reaction suitability

Reaction type: Boc solid-phase peptide synthesis

Boc-His(Trt)-OH Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Boc-His(Trt)-OH Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 286)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688
 zhouyingxiang@highfine.com China 1846 58
Qufu Delu Biotechnology Co., Ltd 13562421518
 deluxe11@163.com China 61 58
Jiangsu Shengkang Meixiang Technology Co., Ltd. 18217475093
 1615396342@qq.com China 4308 58
Chengdu Tachem Co., Ltd 028-61682518; 19983060238
 sales@tachem.cn China 102 58
Lianhe Aigen Pharmatech Co.,Ltd. 18918657159
 sales-Aigen@lianhetech.com China 2998 58
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696
 info@hanhongsci.com China 42917 64
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD 0838-2809458 13350585791
 pharm@biots.cn China 774 58
shanghai Yanfeng biochemical technology Co.,LTD 17721070236 13611955358
 yanfen2023@126.com China 2995 58
Shanghai Binma Technology Co., Ltd. 15262241608
 yzxiajie@163.com China 861 58
Zhangjiagang Specom Biochemical Co., Ltd. 512-0512-58992291,58992287 18606280718
 admin@spbiochem.com China 306 62

32926-43-5()Verwandte Suche:

Trityl candesartan cilexetil p-Toluylsäure Histidin N-(tert-Butoxycarbonyl)-L-histidin N-[(1,1-Dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-serin N-Benzyloxycarbonylglycin Chlortriphenylmethan Phenoxymethylpenicillin N-[(1,1-Dimethylethoxy)carbonyl]-2-methyl-alanin BOC-GLY-LEU-OH 1-Benzyl-N-(tert-butoxycarbonyl)-L-histidin (-)-Methyl(α-methylphenethyl)amin Toluol
  • (S)-2-(tert-butoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid
  • (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid
  • Nα-(tert-butyloxy)carbonyl-Nim-triphenylmethyl-L-histidine
  • N-Boc-His(Trt)-OH
  • (S)-2-(Boc-aMino)-3-(1-trityl-4-iMidazolyl)propionic acid, 95%
  • Boc-His(Trt)-OH >=98.0% (TLC)
  • Boc-His(Trt)-OH, >=98%
  • (S)-L-Boc-his(trt)-oh
  • BOC-N-IM-TRITYL-L-HISTIDINE
  • BOC-HIS(TRT)-OH
  • N-T-BUTOXYCARBONYL-N-TAU-TRITYL-L-HISTIDINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-N-IM-TERT-TRITYL-L-HISTIDINE
  • N-ALPHA-T-BOC-N-IM-TRITYL-L-HISTIDINE
  • N-ALPHA-BOC-N-(IM)-TRITYL-L-HISTIDINE
  • Nα-Boc-N(im)-trityl-L-histidine
  • N-ALPHA-T-BUTYLOXYCARBONYL-N-IM-T-TRITY-L-HISTIDINE
  • L-HISTIDINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-1-(TRIPHENYLMETHYL)-
  • Nα-Boc-Nim-trityl-L-histidine≥ 99.7% (HPLC, Chiral purity)
  • N-Boc-N'-trityl-L-histidine
  • (Tert-Butoxy)Carbonyl His(Trt)-OH
  • 2-((TERT-BUTOXYCARBONYL)AMINO)-3-(1-TRITYL-1H-IMIDAZOL-4-YL)PROPANOIC ACID
  • N-Boc-N'-trityl-L-histidine USP/EP/BP
  • Nα-Boc-Nim-trityl-L-histidine
  • N-[(1,1-Dimethylethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine
  • (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(1-tritylimidazol-4-yl)propanoic acid
  • N-Boc N '- Triphenylmethyl L-histidine
  • Na-(tert-butoxycarbonyl)-N-trityl-L-histidine
  • N-Boc-N'-triphenylmethyl-L-histidine
  • Impurity HA-1
  • N-Boc-N'-trityl-L-histidine, 98%
  • BOC-L-HIS(TRT)-OH
  • Boc-His(trt)
  • Boc-L-His(Trt)
  • His(Trt)-OH
  • 32926-43-5
  • 32925-43-5
  • 32626-43-5
  • C30H31N3O4
  • Amino Acid Derivatives
  • Histidine
  • Peptide Synthesis
  • Specialty Synthesis
  • Boc-Amino Acids and Derivative
  • Boc-Amino acid series
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