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Boc-His(Trt)-OH

Boc-His(Trt)-OH Structure
Boc-His(Trt)-OH structure
CAS No.
32926-43-5
Chemical Name:
Boc-His(Trt)-OH
Synonyms
BOC-HIS(TRT)-OH;Boc-His(trt);His(Trt)-OH;BOC-L-HIS(TRT)-OH;Boc-L-His(Trt);Impurity HA-1;N-Boc-His(Trt)-OH;(S)-L-Boc-his(trt)-oh;Boc-His(Trt)-OH, >=98%;BOC-N-IM-TRITYL-L-HISTIDINE
CBNumber:
CB0342634
Molecular Formula:
C30H31N3O4
Molecular Weight:
497.59
MDL Number:
MFCD00153307
MOL File:
32926-43-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:38:31
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Boc-His(Trt)-OH Properties

Melting point ~130 °C (dec.)
alpha 12.5 º (C=1% IN MEOH)
Boiling point 667.5±55.0 °C(Predicted)
Density 1.16±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Sparingly)
pka 3.17±0.10(Predicted)
form Solid
color White to Off-White
optical activity [α]20/D +12.5±1.0°, c = 1% in methanol
BRN 732035
Major Application peptide synthesis
InChIKey OYXZPXVCRAAKCM-SANMLTNESA-N
SMILES C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)NC(OC(C)(C)C)=O
CAS DataBase Reference 32926-43-5(CAS DataBase Reference)
FDA UNII C9YH4KHR73
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
HS Code  29224999
Storage Class 11 - Combustible Solids

Boc-His(Trt)-OH price More Price(68)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.53034 Boc-His(Trt)-OH Novabiochem? 32926-43-5 25g $1470 2026-04-30 Buy
Sigma-Aldrich 15449 Boc-His(Trt)-OH ≥98.0% (TLC) 32926-43-5 1g $47 2026-04-30 Buy
Sigma-Aldrich 8.53034 Boc-His(Trt)-OH Novabiochem® 32926-43-5 100 g $5180 2026-03-19 Buy
TRC TRC-B656218-1G Boc-His(Trt)-OH 32926-43-5 1g $72 2026-06-03 Buy
TRC TRC-B656218-10G Boc-His(Trt)-OH 32926-43-5 10g $154 2026-06-03 Buy
Product number Packaging Price Buy
8.53034 25g $1470 Buy
15449 1g $47 Buy
8.53034 100 g $5180 Buy
TRC-B656218-1G 1g $72 Buy
TRC-B656218-10G 10g $154 Buy

Boc-His(Trt)-OH Chemical Properties,Uses,Production

Chemical Properties

White to off white powder

Uses

Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.

Uses

Boc-His(Trt)-OH is a histidine derivative. Its a protected histidine derivative for only the critical coupling step. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA.

Preparation

The benzyl 2-tert-butoxycarbonylamino-3-(1-trimethylimidazol-4-yl)propionate was dissolved in methanol (20 mL), and potassium hydroxide was added to the reaction system. The reaction system was stirred for 1 h after THF was added to the reaction system. The solvent is removed under vacuum depressurization, and the mixture is then extracted with water and Et2O. Separate the two phases and acidify the aqueous layer with dilute HCl, extract it with Et2O, combine all the ether organic layer and wash it with water and saline, dry the organic layer with anhydrous magnesium sulfate, filter to remove the solvent, and concentrate the filtrate under vacuum under reduced pressure to obtain Boc-His(Trt)-OH.

Application

N-Boc-N'-Trityl-L-histidine (Boc-His(Trt)-OH) can be used as an intermediate in biochemistry and medicinal chemistry and can be used in the synthesis of peptide drug molecules, vitamins, and molecules with specific biologically active functions. In organic synthesis transformation, the carboxyl group in N-Boc-N'-trityl-L-histidine can undergo corresponding condensation reactions with amine compounds to obtain the corresponding amide products; in addition, in dithionyl chloride Under the action of N-Boc-N'-trityl-L-histidine, intramolecular dehydration cyclization reaction can be performed to obtain cyclic amide derivatives.

reaction suitability

Reaction type: Boc solid-phase peptide synthesis

Boc-His(Trt)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

Boc-His(Trt)-OH Suppliers

Global( 286)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 1846 58
Qufu Delu Biotechnology Co., Ltd 13562421518 deluxe11@163.com China 61 58
Jiangsu Shengkang Meixiang Technology Co., Ltd. 18217475093 1615396342@qq.com China 4308 58
Chengdu Tachem Co., Ltd 028-61682518; 19983060238 sales@tachem.cn China 102 58
Lianhe Aigen Pharmatech Co.,Ltd. 18918657159 sales-Aigen@lianhetech.com China 2998 58
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD 0838-2809458 13350585791 pharm@biots.cn China 747 58
shanghai Yanfeng biochemical technology Co.,LTD 17721070236 13611955358 yanfen2023@126.com China 2996 58
Shanghai Binma Technology Co., Ltd. 15262241608 yzxiajie@163.com China 861 58
Zhangjiagang Specom Biochemical Co., Ltd. 512-0512-58992291,58992287 18606280718 admin@spbiochem.com China 306 62
Supplier Advantage
Suzhou Highfine Biotech Co., Ltd 58
Qufu Delu Biotechnology Co., Ltd 58
Jiangsu Shengkang Meixiang Technology Co., Ltd. 58
Chengdu Tachem Co., Ltd 58
Lianhe Aigen Pharmatech Co.,Ltd. 58
Shanghai Hanhong Scientific Co.,Ltd. 64
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD 58
shanghai Yanfeng biochemical technology Co.,LTD 58
Shanghai Binma Technology Co., Ltd. 58
Zhangjiagang Specom Biochemical Co., Ltd. 62

View Lastest Price from Boc-His(Trt)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-L-His(trt)-OH pictures 2026-09-11 Boc-L-His(trt)-OH
32926-43-5
 1kg 98%;99% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
Boc-His(Trt)-OH pictures 2026-09-02 Boc-His(Trt)-OH
32926-43-5
 $6.00-8.00 1kg 99% Henan Fengda Chemical Co., Ltd
N-Boc-N'-trityl-L-histidine pictures 2025-04-04 N-Boc-N'-trityl-L-histidine
32926-43-5
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

Boc-His(Trt)-OH Spectrum

Boc-His(Trt)-OH(32926-43-5)1HNMR

32926-43-5(Boc-His(Trt)-OH)Related Search:

N-BOC-O-Benzyl-L-serine Boc-D-Ser(Bzl)-OH N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol N-Boc-N'-Cbz-L-lysine Trityl candesartan cilexetil
p-Toluic acid L-Histidine N-Boc-L-Histidine N-Carbobenzyloxyglycine Triphenylmethyl Chloride
PENICILLIN V Boc-Aib-OH Boc-Gly-Leu-OH (-)-2-[Methylamino]-1-phenylpropane Toluene
1-Triphenylmethyl-4-methylimidazole H-His(Bzl)-OH Boc-His(Bzl)-OH

1of4

(S)-2-(tert-butoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid Nα-(tert-butyloxy)carbonyl-Nim-triphenylmethyl-L-histidine N-Boc-His(Trt)-OH (S)-2-(Boc-aMino)-3-(1-trityl-4-iMidazolyl)propionic acid, 95% Boc-His(Trt)-OH >=98.0% (TLC) Boc-His(Trt)-OH, >=98% (S)-L-Boc-his(trt)-oh BOC-N-IM-TRITYL-L-HISTIDINE BOC-HIS(TRT)-OH N-T-BUTOXYCARBONYL-N-TAU-TRITYL-L-HISTIDINE N-ALPHA-TERT-BUTYLOXYCARBONYL-N-IM-TERT-TRITYL-L-HISTIDINE N-ALPHA-T-BOC-N-IM-TRITYL-L-HISTIDINE N-ALPHA-BOC-N-(IM)-TRITYL-L-HISTIDINE Nα-Boc-N(im)-trityl-L-histidine N-ALPHA-T-BUTYLOXYCARBONYL-N-IM-T-TRITY-L-HISTIDINE L-HISTIDINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-1-(TRIPHENYLMETHYL)- Nα-Boc-Nim-trityl-L-histidine≥ 99.7% (HPLC, Chiral purity) N-Boc-N'-trityl-L-histidine (Tert-Butoxy)Carbonyl His(Trt)-OH 2-((TERT-BUTOXYCARBONYL)AMINO)-3-(1-TRITYL-1H-IMIDAZOL-4-YL)PROPANOIC ACID N-Boc-N'-trityl-L-histidine USP/EP/BP Nα-Boc-Nim-trityl-L-histidine N-[(1,1-Dimethylethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(1-tritylimidazol-4-yl)propanoic acid N-Boc N '- Triphenylmethyl L-histidine Na-(tert-butoxycarbonyl)-N-trityl-L-histidine N-Boc-N'-triphenylmethyl-L-histidine Impurity HA-1 N-Boc-N'-trityl-L-histidine, 98% BOC-L-HIS(TRT)-OH Boc-His(trt) Boc-L-His(Trt) His(Trt)-OH 32926-43-5 32925-43-5 32626-43-5 C30H31N3O4 Amino Acid Derivatives Histidine Peptide Synthesis Specialty Synthesis Boc-Amino Acids and Derivative Boc-Amino acid series