ChemicalBook >> CAS DataBase List >>Cyclosporine A
Cyclosporine A
- CAS No.
- 59865-13-3
- Chemical Name:
- Cyclosporine A
- Synonyms
- CICLOSPORIN;CYCLOSPORINE A;Restasis;sandimmune;CICLOSPORIN A;Neoral;Cyclospori;CiclosporinOralSolution;30-Ethyl-33-(1-hydroxy-2-methyl-hex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone;CL285
- CBNumber:
- CB00128804
- Molecular Formula:
- C62H111N11O12
- Molecular Weight:
- 1202.61
- MDL Number:
- MFCD00274558
- MOL File:
- 59865-13-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-27 17:00:41
| Melting point | 148-151°C |
|---|---|
| Boiling point | 838.63°C (rough estimate) |
| alpha | D20 -244° (c = 0.6 in chloroform); D20 -189° (c = 0.5 in methanol) |
| Density | 0.9913 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| Flash point | 87℃ |
| storage temp. | -20°C |
| solubility | ethanol: 30 mg/mL |
| form | solid |
| pka | 13.32±0.70(Predicted) |
| color | white |
| optical activity | -18922 (methanol) |
| Water Solubility | Soluble in dimethyl sulfoxide and ethanol. Insoluble in water. |
| Merck | 14,2752 |
| BRN | 3647785 |
| Stability | Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChIKey | PMATZTZNYRCHOR-CGLBZJNRSA-N |
| CAS DataBase Reference | 59865-13-3(CAS DataBase Reference) |
| EWG's Food Scores | 4 |
| NCI Dictionary of Cancer Terms | cyclosporine |
| FDA UNII | 83HN0GTJ6D |
| NCI Drug Dictionary | cyclosporine |
| ATC code | L04AD01,S01XA18 |
| Proposition 65 List | Ciclosporin (Cyclosporin A; Cyclosporine) |
| IARC | 1 (Vol. 50, 100A) 2012 |
| EPA Substance Registry System | Cyclosporin A (59865-13-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H350-H360FD | |||||||||
| Precautionary statements | P201-P202-P264-P270-P301+P312-P308+P313 | |||||||||
| Hazard Codes | T,Xn,F | |||||||||
| Risk Statements | 45-60-22-40-36-20/21/22-11 | |||||||||
| Safety Statements | 53-45-36/37-24/25-22-26-16 | |||||||||
| RIDADR | UN 1648 3 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GZ4120000 | |||||||||
| HS Code | 29419090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazardous Substances Data | 59865-13-3(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 in mice, rats, rabbits (mg/kg): 107, 25, >10 i.v.; 2329, 1480, >1000 orally (Ryffel) | |||||||||
| NFPA 704 |
|
Cyclosporine A price More Price(135)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C2163000 | Ciclosporin European Pharmacopoeia (EP) Reference Standard | 59865-13-3 | 100 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | C-093 | Cyclosporin A solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? | 59865-13-3 | 1mL | $275 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1158504 | Cyclosporine United States Pharmacopeia (USP) Reference Standard | 59865-13-3 | 50mg | $1530 | 2026-04-30 | Buy |
| Sigma-Aldrich | 239835 | Cyclosporin A | 59865-13-3 | 100mg | $102 | 2022-05-15 | Buy |
| TCI Chemical | C2408 | Cyclosporin A >97.0%(HPLC)(N) | 59865-13-3 | 1g | $248 | 2026-04-30 | Buy |
Cyclosporine A Chemical Properties, Uses, Production
Description
Cyclosporine A (CsA) is a neutral lipophilic compound first isolated in the 1970s from the fungal species Tolypocladium inflatum gams. CsA is a cyclic polypeptide consisting of 11 amino acids, with a molecular weight of 1202 daltons. It was found to have potent immunosuppressive properties and was initially used in the late 1970s to prevent organ rejection following transplantation. CsA first became available for general use in North America in 1983 and is now perhaps the most widely used drug to prevent graft rejection in transplantation medicine. The spectrum of conditions for which CsA is now being used has broadened, with reports of its benefit in several autoimmune and cutaneous diseases.
Biological Functions
Cyclosporine A is an immunosuppressant that binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM. Cyclosporine A also inhibits CD11a/CD18 adhesion.
Cyclosporine A Preparation Products And Raw materials
Global Suppliers ( 789)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Pharmaceutical Technology co.,ltd | 0510-88771160 18051901298 | 2013446823@qq.com | China | 53 | 61 |
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| SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD | 0755-83725350 13380397412 | 3001280422@qq.com | China | 10000 | 58 |
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Related articles
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- Jun 23,2025
View Latest Price from Cyclosporine A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-01 | Cyclosporine A
59865-13-3
|
1kg | 99% | 10000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | ||
 |
2022-12-29 | CYCLOSPORINE
79217-60-0
|
$1.00 | 10g | 99.5% | 1000kg | Guangzhou Biocar Biotechnology Co.,Ltd. | |
 |
2019-07-31 | cyclosporine A
59865-13-3
|
$1.00 | 1g | 99% | Cangzhou Wanyou New Material Technology Co.,Ltd |
-
- Cyclosporine A
59865-13-3
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- CYCLOSPORINE
79217-60-0
- $1.00
- 99.5%
- Guangzhou Biocar Biotechnology Co.,Ltd.
-
- cyclosporine A
59865-13-3
- $1.00
- 99%
- Cangzhou Wanyou New Material Technology Co.,Ltd
59865-13-3 (Cyclosporine A) Related Search:
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(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
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osporin A
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(3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
